The crew at Real Hardware Reviews say that, if you are looking for a true desktop replacement laptop, you should check out the ASUS ROG G752VS laptop they just reviewed. Here's a quote from the full review:
The arrival of Pascal has allowed NVIDIA to shove nearly full powered desktop GPUs into the hands of laptop manufacturers. Asus combining a GTX 1070 with an unlocked Core i7 mobile processor and an SSD allows you desktop levels of performance in a form factor that allows you to move around a lot more freely than most "desktop replacement" laptops of the past. You’ll be hard pressed to beat the pure numbers that this laptop will crank out.